Following up on our country deep-dive series, we now turn to Luxembourg, a small but strategically positioned ecosystem that continues to punch above its weight in European innovation. Known for its strength in finance, space, and cross-border industry, the country has steadily expanded into healthtech, climate tech, robotics, and digital infrastructure.
While Luxembourg’s startup scene may be more compact than larger European hubs, it benefits from strong institutional backing, international talent, and close proximity to major EU markets. The ecosystem increasingly reflects a blend of regulated-industry expertise and deep technical ambition, with companies building in areas such as FundTech, biotech, industrial automation, and circular economy technologies.
In this article, we highlight 10 of the most promising Luxembourg-based startups founded from 2021 onwards. Presented in alphabetical order, the selection focuses on companies that have secured funding, developed defined products, and are positioning themselves for continued growth into 2026 and beyond.
Founded in 2021, buildbuild is an automation platform designed for construction and real estate companies. The software centralises project management, budgeting, documentation, and reporting into a single workspace, aiming to reduce the administrative burden typically associated with construction projects.
The platform automates processes such as invoice management, budget tracking, change approvals, and status reporting, while integrating with tools like SAP, Oracle, and QuickBooks. By replacing fragmented spreadsheets and manual paperwork with structured workflows, buildbuild seeks to improve cost control and operational visibility across projects. With a last round dated in 2023, theyhave secured over €2.2 million to expand their product and user base.
Founded in 2024, Cyberr® is a cybersecurity marketplace connecting companies with vetted cybersecurity professionals across Europe and North America. The platform hosts more than 200,000 active job seekers covering domains such as cloud security, incident response, governance, penetration testing, and security architecture.
Cyberr uses a data-driven matching system built on large cybersecurity datasets to connect organisations directly with specialists, removing the need for traditional recruitment agencies. Companies can post roles, review verified profiles and work samples, and negotiate directly with candidates under a subscription-based model. The company has secured €6.65 million to expand its platform and talent network.
Founded in 2024, Exobiosphere is developing what it describes as the first space-based contract research organisation. The company uses microgravity environments to conduct high-throughput biological experiments, aiming to create disease models that behave differently in space than they do on Earth.
Its Orbital High-Throughput System enables automated testing in orbit, with applications in areas such as oncology, neurodegeneration, ageing, and cardiovascular disease. By studying how cells respond in microgravity, Exobiosphere seeks to uncover new drug targets and improve early-stage drug development. To date, they have raised €2 million in funding in order to develop their platform and expand partnerships across research institutions and industry.
Founded in 2022, Fundvis is a FundTech platform designed to simplify oversight and compliance across the financial industry. The software centralises onboarding, monitoring, incident management, and regulatory reporting for banks, asset managers, depositaries, insurers, and private equity firms.
The platform automates due diligence, risk scoring, KPI tracking, and regulatory reporting aligned with European frameworks such as DORA and GDPR. By replacing spreadsheet-based oversight with structured workflows and dashboards, Fundvis aims to improve transparency and auditability across third-party provider networks. The company has raised €2.59 million, with its latest funding round completed in 2025.
Founded in 2024, Helical is building what it calls a virtual AI lab for biology. The company develops an application layer that allows pharmaceutical and biotech teams to deploy and personalise biological foundation models for research and drug discovery.
Its platform provides biologists with a self-serve environment to design and evaluate experiments in silico, while offering machine learning engineers tools for model customisation and experiment tracking. Helical focuses on areas such as target identification, biomarker discovery, therapeutic design, and patient stratification, aiming to bridge the gap between AI predictions and real-world research decisions. The company has raised €3 million to further develop its platform and expand industry deployments.
Founded in 2021, Kidola provides software designed to digitise childcare management and child monitoring processes. The platform allows childcare providers to track attendance, share updates with parents, and manage administrative tasks digitally.
By replacing paper-based systems with a centralised application, Kidola aims to improve communication and operational efficiency in early childhood settings. The company has raised €1.9 million, with its most recent funding round completed in 2025.
Founded in 2022, MDsim is a healthtech company developing AI-powered digital twin technology for the spine. The platform converts clinical data into personalised biomechanical models that allow clinicians to analyse spinal mechanics, simulate disease progression, and explore potential treatment strategies.
Its software supports prevention and surgical planning by enabling surgeons and medical device companies to test different scenarios in a virtual environment before intervention. By modelling spine biomechanics digitally, MDsim aims to improve decision-making, reduce complications, and support more personalised care pathways. With its latest funding round reported in 2025, they have raised a total of €2.3 million.
Founded in 2021, R3 Robotics develops automated robotic systems for the industrial dismantling of electric vehicle components. The company focuses on end-of-life processing of complex systems such as battery packs, e-drives, and power electronics, aiming to replace manual disassembly with scalable, repeatable automation.
Its platform combines robotics, adaptive motion planning, and specialised tooling to safely dismantle high-voltage components at an industrial scale. R3 offers both Disassembly-as-a-Service and Robotics-as-a-Service models, supporting recycling, reuse, and material recovery operations. The company has raised €28.5 million, with its latest funding round completed in 2026.
Founded in 2025, S.P.O.N.S.O.R. (SCOP) is an AI-powered climate fintech platform focused on scaling climate mitigation project finance. The company aims to address what it sees as a structural gap in the market: not a shortage of capital, but a shortage of well-structured, investment-ready projects.
SPONSOR combines project finance expertise with digital tools that help structure, evaluate, and connect stakeholders across climate infrastructure projects. By creating a centralised platform for collaboration and deal preparation, the company seeks to reduce delays and improve the flow of bankable projects in a sector estimated at $2 trillion annually. To date, they have raised €1.1 million to develop and expand their platform.
Founded in 2021, Uplift360 develops chemical recycling technologies aimed at recovering and reusing advanced materials such as carbon fibre and aramids. These materials are widely used in aerospace, defence, and high-performance manufacturing but are typically landfilled or incinerated at the end of their lifecycle.
Uplift360’s processes focus on low-energy chemical treatments that separate and regenerate high-value components for reuse, supporting more circular supply chains. By addressing both disposal costs and material scarcity, the company aims to reduce environmental impact while strengthening European industrial resilience. Uplift360 has raised €8.45 million, with its most recent funding round completed in 2026.
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Read the orginal article: https://www.eu-startups.com/2026/02/big-ideas-from-a-small-nation-10-of-the-most-promising-luxembourg-startups-to-watch-in-2026/
